Methylation of p53 protein by KMT7/SET7 is the first reported KMT-mediated methylation occasion on a non-histone protein 18 Since that discovery, several KMTs, in addition to KDM1A, have been recognized as p53 regulators that methylate or demethylate p53 protein, making p53 probably the most extensively studied non-histone protein present process lysine methylation 4 , 13 , 16 , 18 , 162 Here we use p53 as a mannequin to debate the features of lysine methylation of non-histone proteins.
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